Methanol → 1-Benzoyl-2-methyl-6-methoxypiperidine

HRID 26351

Reaktionsgleichung

Reaktionsgleichung von HRID 26351
[C:1]([N:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH:10]1[CH3:15])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:16][OH:17]>F[B-](F)(F)F.C[N+](C)(C)C>[C:1]([N:9]1[CH:14]([O:17][CH3:16])[CH2:13][CH2:12][CH2:11][CH:10]1[CH3:15])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 887MethanolHCID 275047N-Benzoyl-2-methylpiperidine2×

Produkt 1

HCID 213228541-Benzoyl-2-methyl-6-methoxypiperidineAusbeute 77,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 12621Tetramethylammonium tetrafluoroborateKatalysator

Versuchsvorschrift

In the same manner as in Example 5, there are electrolyzed 43.8 g of 1-benzoyl-2-methylpiperidine and 60.2 g of methanol in the presence of 0.3 g of tetramethylammonium tetrafluoroborate as conducting salt. After throughput of 2.5 Faraday per mol of 1-benzoyl-2-methylpiperidine the current is switched off. After work-up of the electrolysis solution, 39.0 g of 1-benzoyl-2-methyl-6-methoxypiperidine (boiling point 78°-81° C./0.1 mm Hg; nD25 =1.5340) are obtained which corresponds to a product yield of 77.5% and a current efficiency of 62.0%.

Quellen und Nachweise

ORD-Eintrag
ord-bfde8daec3d34f83be4c725b8a450688
Quelldatensatz
uspto-grants-1979_04
Patentnummer
US04149941

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