m-Chloroperbenzoic acid → 3-(4-phenylthiazol-2-yl)pyridine-N-oxide

HRID 263569Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 263569
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[S:8][CH:9]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[N:11]=2)[CH:2]=1.ClC1C=CC=C(C(OO)=[O:26])C=1>ClCCl>[C:12]1([C:10]2[N:11]=[C:7]([C:3]3[CH:2]=[N+:1]([O-:26])[CH:6]=[CH:5][CH:4]=3)[S:8][CH:9]=2)[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Komponenten

4

Edukt 2

HCID 70297m-Chloroperbenzoic acidHCID 7010154-Phenyl-2-(pyridin-3-yl)thiazole

Produkt 1

HCID 187071743-(4-phenylthiazol-2-yl)pyridine-N-oxideAusbeute 28,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

In 50 ml of dichloromethane was dissolved 1 g of 2-(pyridin-3-yl)-4-phenylthiazole. Thereto was added 900 mg of m-chloroperbenzoic acid at room temperature. The mixture was stirred at the same temperature for 2 hours. The reaction mixture was washed with an aqueous sodium hydrogencarbonate solution and dried. The solvent was removed by distillation. The residue was recrystallized from ethyl acetate to obtain 306 mg of 3-(4-phenylthiazol-2-yl)pyridine-N-oxide as a brown powder.

Aufarbeitung

  1. washThe reaction mixture was washed with an aqueous sodium hydrogencarbonate solution
  2. customdried
  3. customThe solvent was removed by distillation
  4. customThe residue was recrystallized from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-7a7818a855a343b780c827d27c40d1ec
Quelldatensatz
uspto-grants-1997_07
Patentnummer
US05643932

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