1-Butanol, 4-bromo-, 1-acetate → 4-(2-Anilino-6-chloro-9H-purin-9-yl)butyl acetate

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	1-Butanol, 4-bromo-, 1-acetate	HCID 78491	—
Edukt	9H-Purin-2-amine, 6-chloro-N-phenyl-	HCID 5271882	—
Lösungsmittel	chloroform N,N-dimethylformamide	HCID 21754633	—
Produkt	4-(2-Anilino-6-chloro-9H-purin-9-yl)butyl acetate	HCID 385891	45%

Reaktionsschritte

Reaction between 2-anilino-6-chloropurine and 4-acetoxybutyl bromide was performed as described in A.a., above, giving 2-anilino-6-chloro-9-(4-acetoxybutyl) purine in a 45% yield (from DMF/chloroform), mp 195°-197° C. 1H NMR δ9.98 (s, 2-NH), 8.32 (s, 8-H), 7.31 (m, C6H5), 4.20 (t, 1'-CH2), 4.02 (t, 4'-CH2), 1.95 (s, CH3), 1.92, 1.58 (m, 2'/3'CH2).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US05646155
Quelldatensatz	uspto-grants-1997_07
ORD ID	ord-ac9a61d7a1d2420ebcca417076648ca9
Quellennotiz	uspto-grants-1997_07