Iodine → HCID 178418276, Verbindung

HRID 264782

Reaktionsgleichung

Reaktionsgleichung von HRID 264782
[Mg:1].II.[Br:4]CCBr.Br[C:9]1[CH:14]=CC(OC)=[CH:11][CH:10]=1.[CH2:17]1[CH2:21][O:20][CH2:19][CH2:18]1>>[CH2:11]([Mg:1][Br:4])[C:10]1[CH:18]=[CH:17][C:21]([O:20][CH3:19])=[CH:14][CH:9]=1

Komponenten

6

Edukt 5

HCID 807IodineHCID 77304-BromoanisoleHCID 78391,2-DibromoethaneHCID 8028TetrahydrofuranHCID 5462224Magnesium

Produkt 1

HCID 178418276HCID 178418276, Verbindung

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

Magnesium (36 g, 1.5 mmol), iodine (a few Crystals) and THF (1 L) were heated under nitrogen, with stirring, at reflux for 15 min. The mixture was cooled to 20° C., stirring stopped, and 1,2-dibromoethane (2.5 ml) added. After an exothermic reaction was observed (a few min) stirring was restarted which was accompanied by a rise in temperature to 35° C. The mixture was cooled to 20° C. and 4-bromoanisole slowly added over 1 h at 14°-18° C. with cooling. Stirring was continued for 10 min after the addition was complete.

Aufarbeitung

  1. temperatureat reflux for 15 min
  2. stirringstirring
  3. customAfter an exothermic reaction
  4. stirringstirring
  5. customwas accompanied by a rise in temperature to 35° C
  6. temperatureThe mixture was cooled to 20° C.
  7. temperaturewith cooling
  8. stirringStirring
  9. additionafter the addition

Quellen und Nachweise

ORD-Eintrag
ord-f9bb80e2e474433b8adbe744c6976f8e
Quelldatensatz
uspto-grants-1997_07
Patentnummer
US05646286

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