1(3H)-Isobenzofuranone, 3-bromo- → HCID 178440074, Verbindung

HRID 265179Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 265179
[OH:1][C:2]([C:5]1[N:6]=[C:7]([CH2:13][CH2:14][CH3:15])[NH:8][C:9]=1[C:10]([OH:12])=[O:11])([CH3:4])[CH3:3].Br[CH:17]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:19](=[O:20])[O:18]1>>[OH:1][C:2]([C:5]1[N:6]=[C:7]([CH2:13][CH2:14][CH3:15])[NH:8][C:9]=1[C:10]([O:12][CH:17]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:19](=[O:20])[O:18]1)=[O:11])([CH3:4])[CH3:3]

Komponenten

3

Edukt 2

HCID 962181(3H)-Isobenzofuranone, 3-bromo-HCID 178440085HCID 178440085, Verbindung

Produkt 1

HCID 178440074HCID 178440074, VerbindungAusbeute 94,8 %

Versuchsvorschrift

Following a procedure similar to that described in Preparation 31, but using 1.06 g of 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylic acid [prepared as described in Preparation 22(i)] and 1.15 g of 3-bromophthalide, 1.63 g of the title compound were obtained as an amorphous solid.

Aufarbeitung

  1. customthat described in Preparation 31

Quellen und Nachweise

ORD-Eintrag
ord-d03dc2ac75464b9580a0a9bebb45fa60
Quelldatensatz
uspto-grants-1997_07
Patentnummer
US05646171

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