Hydrochloric Acid → Nafimidone monohydrochloride

HRID 26544

Reaktionsgleichung

Reaktionsgleichung von HRID 26544
[ClH:1].[CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:12]([CH2:14][N:15]1[CH:19]=[CH:18][N:17]=[CH:16]1)=[O:13]>>[ClH:1].[CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:12]([CH2:14][N:15]1[CH:19]=[CH:18][N:17]=[CH:16]1)=[O:13]

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 512002-(1H-Imidazol-1-yl)-1-(2-naphthalenyl)ethanone

Produkt 1

HCID 51199Nafimidone monohydrochloride

Versuchsvorschrift

Ethereal hydrogen chloride is added dropwise to a solution of 1.0 g. 1-(2-naphthoylmethyl)imidazole in 100 ml. anhydrous benzene until precipitation is complete. The product is filtered, washed with ether, air dried and recrystallized from methanol/acetone to yield 1-(2-naphthoylmethyl)imidazole hydrochloride, m.p. 226°-228.5° C. (decomp.)

Aufarbeitung

  1. customanhydrous benzene until precipitation
  2. filtrationThe product is filtered
  3. washwashed with ether, air
  4. customdried
  5. customrecrystallized from methanol/acetone

Quellen und Nachweise

ORD-Eintrag
ord-6ba27d46b2f5423ca8e9dc5ac6a8baa3
Quelldatensatz
uspto-grants-1979_04
Patentnummer
US04150153

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