Sodium Hydroxide → 4-(4-Chlorobutyloxy)benzoic acid

HRID 265892Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 265892
[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:16]=[CH:15][C:10]([C:11]([O:13]C)=[O:12])=[CH:9][CH:8]=1.[OH-].[Na+].OS([O-])(=O)=O.[K+]>C(O)C>[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([C:11]([OH:13])=[O:12])=[CH:15][CH:16]=1

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 516920Potassium bisulfateHCID 14575308Methyl 4-(4-chlorobutoxy)benzoate

Produkt 1

HCID 190341754-(4-Chlorobutyloxy)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A mixture of 24-2 (3.0 g, 12.4 mmol), 1N NaOH (30 mL), and ethanol was heated at 60° C. for 1.0 hour. The cooled reaction mixture was acidified with 10% KHSO4 and then extracted with EtOAc. The EtOAc portion was washed with brine, dried (MgSO4) and concentrated to give 24-3 as a white solid.

Aufarbeitung

  1. customThe cooled reaction mixture
  2. extractionextracted with EtOAc
  3. washThe EtOAc portion was washed with brine
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-21803ed5b24647c39e159b4ca30aa559
Quelldatensatz
uspto-grants-1997_07
Patentnummer
US05648368

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