Hydrochloric Acid → 4-[2-(N-Benzylimidazol-4-yl)ethyloxy]benzoic acid

HRID 265896Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 265896
[CH2:1]([N:8]1[CH:12]=[C:11]([CH2:13][CH2:14][O:15][C:16]2[CH:25]=[CH:24][C:19]([C:20]([O:22]C)=[O:21])=[CH:18][CH:17]=2)[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].Cl>CO>[CH2:1]([N:8]1[CH:12]=[C:11]([CH2:13][CH2:14][O:15][C:16]2[CH:17]=[CH:18][C:19]([C:20]([OH:22])=[O:21])=[CH:24][CH:25]=2)[N:10]=[CH:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 18928610Methyl 4-[2-(1-Benzylimidazol-4-yl)ethyloxy]benzoate

Produkt 1

HCID 158507574-[2-(N-Benzylimidazol-4-yl)ethyloxy]benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of the ester 25-4 (170 mg, 0.51 mmol), CH3OH (10 mL), and 1N NaOH (5 mL) was stirred for 20 hours at ambient temperature. The cooled reaction mixture was acidified with 1N HCl (5 mL) and extracted with EtOAc. The EtOAc portion was concentrated to give 25-5 as a gelataneous solid.

Aufarbeitung

  1. customThe cooled reaction mixture
  2. extractionextracted with EtOAc
  3. concentrationThe EtOAc portion was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-706bd961279a411c84650ee391878fb9
Quelldatensatz
uspto-grants-1997_07
Patentnummer
US05648368

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