4-Phenylpiperidine-4-carboxamide monohydrochloride → 1-[2-[3-(3,4-Dimethoxy-phenyl)-1-(3,4,5-triethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl]-4-phenyl-piperidine-4-carboxylic acid amide

HRID 265926

Reaktionsgleichung

Reaktionsgleichung von HRID 265926
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2([CH2:33][CH2:34]CS([O-])(=O)=O)[CH2:15][CH2:14][N:13]([C:16](=[O:32])[C:17]3[CH:22]=[C:21]([O:23][CH2:24][CH3:25])[C:20]([O:26][CH2:27][CH3:28])=[C:19]([O:29][CH2:30][CH3:31])[CH:18]=3)[CH2:12]2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].Cl.[C:41]1([C:47]2([C:53]([NH2:55])=[O:54])[CH2:52][CH2:51][NH:50][CH2:49][CH2:48]2)[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2([CH2:33][CH2:34][N:50]3[CH2:49][CH2:48][C:47]([C:41]4[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=4)([C:53]([NH2:55])=[O:54])[CH2:52][CH2:51]3)[CH2:15][CH2:14][N:13]([C:16](=[O:32])[C:17]3[CH:18]=[C:19]([O:29][CH2:30][CH3:31])[C:20]([O:26][CH2:27][CH3:28])=[C:21]([O:23][CH2:24][CH3:25])[CH:22]=3)[CH2:12]2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Komponenten

3

Edukt 2

HCID 30171294-Phenylpiperidine-4-carboxamide monohydrochlorideHCID 867509142-[3-(3,4-Dimethoxy-phenyl)-1-(3,4,5-triethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate

Produkt 1

HCID 536553231-[2-[3-(3,4-Dimethoxy-phenyl)-1-(3,4,5-triethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl]-4-phenyl-piperidine-4-carboxylic acid amide

Versuchsvorschrift

Prepare by the method of example 3.3 using 2-[3-(3,4-dimethoxy-phenyl)-1-(3,4,5-triethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate (8 mmol) and 4-phenyl-piperidine-4-carboxylic acid amide hydrochloride (12 mmol). Chromatograph on silica gel to give the title compound.

Quellen und Nachweise

ORD-Eintrag
ord-e2c004a8d6824dffb28318954dc090ab
Quelldatensatz
uspto-grants-1997_07
Patentnummer
US05648366

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