Acetonitrile → 2-Methylquinazoline

HRID 266113

Reaktionsgleichung

[NH2:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4](C1C=CC=CC=1)=O.[C:16](#[N:18])[CH3:17]>>[CH3:17][C:16]1[N:18]=[CH:4][C:3]2[C:2](=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:1]=1

Komponenten

Edukt 2

HCID 6342Acetonitrile

HCID 760802-Aminobenzophenone

Produkt 1

HCID 5889872-Methylquinazoline

Versuchsvorschrift

In this method, the 2-aminobenzophenone derivative (IV) is reacted with acetonitrile to give the 2-methylquinazoline derivative (IX). The compound (IX) is subjected to bromination to give the 2-bromomethylquinazoline derivative (II-4). The reaction of the compound (IV) with acetonitrile can be carried out according to the same manner as that of Method D. The bromination of the compound (IX) can be carried out according to the same manner as that of the bromination of the compound (VII) in Method C.

Quellen und Nachweise

ORD-Eintrag: ord-c9dd40a373ab4a39b3ccca2a27630ca6
Quelldatensatz: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05650410

Verknüpfte Notizen

Wird geladen…