Triethyl 2-phosphonopropionate → 2-Phosphonopropionic acid
Reaktionsgleichung
C([O:3][C:4](=[O:15])[CH:5]([P:7]([O:12]CC)([O:9]CC)=[O:8])[CH3:6])C>Cl>[P:7]([CH:5]([CH3:6])[C:4]([OH:15])=[O:3])([OH:12])([OH:9])=[O:8]Komponenten
3
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of ethyl-2-(diethoxyphosphinyl)propionate (15 g., 0.063 moles) in 6 N hydrochloric acid (150 ml.) is heated to reflux for 2.5 hours. After this time, the reaction vessel is fitted with a Dean-Stark trap and heated at reflux an additional thirty minutes. The reaction mixture is concentrated in vacuo to yield 2-phosphonopropionic acid (quantitative).
Aufarbeitung
- temperatureis heated
- temperatureto reflux for 2.5 hours
- customAfter this time, the reaction vessel is fitted with a Dean-Stark trap
- temperatureheated
- temperatureat reflux an additional thirty minutes
- concentrationThe reaction mixture is concentrated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-51634a379c774f2fb0c7ff187d1ea7c9
- Quelldatensatz
- uspto-grants-1979_04
- Patentnummer
- US04151172
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