Chloroacetyl chloride → 4-Chloroacetamido-3-hydroxypyridine

HRID 266915

Reaktionsgleichung

Reaktionsgleichung von HRID 266915
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[OH:8].[Cl:9][CH2:10][C:11](Cl)=[O:12]>>[Cl:9][CH2:10][C:11]([NH:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[OH:8])=[O:12]

Komponenten

3

Edukt 2

HCID 6577Chloroacetyl chlorideHCID 27624194-Amino-3-hydroxypyridine

Produkt 1

HCID 190316634-Chloroacetamido-3-hydroxypyridine

Versuchsvorschrift

A solution of 4-amino-3-hydroxypyridine (7 g, 0.06 mol) and chloroacetyl chloride (50 ml) was refluxed for 2 hours, cooled and the excess solvent was removed by vacuum distillation. The crude material was dissolved in water, neutralized with Na2CO3 and the solid precipitated filtered and air dried to give the desired product, m.p. 155°-158° C. The structural assignment was supported by the proton NMR spectrum.

Aufarbeitung

  1. temperaturecooled
  2. customthe excess solvent was removed by vacuum distillation
  3. dissolutionThe crude material was dissolved in water
  4. customthe solid precipitated
  5. filtrationfiltered
  6. customair dried

Quellen und Nachweise

ORD-Eintrag
ord-0e717692545847bf99de662dd998060e
Quelldatensatz
uspto-grants-1997_07
Patentnummer
US05652363

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