Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Water | HCID 962 | — |
| Edukt | 6-Nitro-3-phenylacetamidobenzoic acid | HCID 193864 | — |
| Edukt | Penicillin V Potassium | HCID 23676814 | — |
| Lösungsmittel | Triethylamine | HCID 8471 | — |
| Produkt | 6-Aminopenicillanic acid | HCID 11082 | 86,1% |
Reaktionsschritte
290 g of carrier-bound penicillinacylase according to Example 4, having an enzymatic activity of 2,803 U (NIPAB test) and 138 g of potassium penicillin V are added to 2,000 ml of water and stirred for 9 hours at 38°C. The pH value is kept constant at 7.8 by continuous addition of triethylamine. The mixture is worked up as described in Example 1. Yields of 6-APA 64.3 g (86.1% of theory); purity 97.4%.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US03941756 |
|---|
| Quelldatensatz | uspto-grants-1976_03 |
|---|
| ORD ID | ord-b637f9b0888d47a1a842be6a33c686f8 |
|---|
| Quellennotiz | uspto-grants-1976_03 |
|---|
