Ethyl orthoformate → 5-Methyl-1-[alpha-(o-chlorophenyl)-o-tolyl]imidazole
Reaktionsgleichung
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]1[C:10](=[CH:12][CH:13]=[CH:14][CH:15]=1)[NH2:11].[CH:16](OCC)(OCC)OCC.[CH3:26][C:27]1([CH2:32][NH2:33])OCCO1>[Ti](Cl)(Cl)(Cl)Cl>[CH3:26][C:27]1[N:11]([C:10]2[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=2[CH2:8][C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[CH:16]=[N:33][CH:32]=1Komponenten
5
Versuchsvorschrift
In the manner given in Example 3, α-(0-chlorophenyl)-0-toluidine is reacted with triethyl orthoformate, the resulting oil is heated with 2-methyl-2-(aminomethyl)-1,3-dioxolane, and the resulting product treated with titanium tetrachloride to give 5-methyl-1-[α-(0-chlorophenyl)-0-tolyl]imidazole.
Quellen und Nachweise
- ORD-Eintrag
- ord-34e25510f4724abf9cc493908612ca66
- Quelldatensatz
- uspto-grants-1976_03
- Patentnummer
- US03941802
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