Tryptamine → HCID 15083993, Verbindung

HRID 267553

Reaktionsgleichung

Reaktionsgleichung von HRID 267553
[NH2:1][CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.[C:13](O)(=[O:19])[CH2:14][CH2:15][C:16]([CH3:18])=O>CCCCOCCO>[CH3:18][C:16]12[C:5]3[NH:6][C:7]4[C:12]([C:4]=3[CH2:3][CH2:2][N:1]1[C:13](=[O:19])[CH2:14][CH2:15]2)=[CH:11][CH:10]=[CH:9][CH:8]=4

Komponenten

4

Edukt 2

HCID 1150TryptamineHCID 11579Levulinic Acid

Produkt 1

HCID 15083993HCID 15083993, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 81332-ButoxyethanolLösungsmittel

Versuchsvorschrift

Tryptamine (112.15 g.), levulinic acid (97.6 g., 85.6 ml.) and butyl cellosolve (1 liter) are refluxed under nitrogen for 16 hours and the solvent is removed. The residue is successively washed with water, dilute aqueous sodium hydroxide, water, dilute aqueous hydrochloric acid, water and dried. Trituration of the crude product, decomposition at 252°-262°C., with methanol, and then with benzene, and drying provides 120.4 g. of the title compound, decomposition at 259°-263°C.; λmaxKBr 3.09, 6.01, 6.17, 13.38 μ.

Aufarbeitung

  1. customthe solvent is removed
  2. washThe residue is successively washed with water, dilute aqueous sodium hydroxide, water, dilute aqueous hydrochloric acid, water
  3. customdried
  4. dry with materialTrituration of the crude product, decomposition at 252°-262°C., with methanol, and then with benzene, and drying
  5. customprovides 120.4 g

Quellen und Nachweise

ORD-Eintrag
ord-57fe05309dae4472a9ac00f0582f7e80
Quelldatensatz
uspto-grants-1976_03
Patentnummer
US03943148

Verknüpfte Notizen

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