2-Propylaminoacetaldehyde → 2-[1-Propyl-3-(5-cyclobutyl-1,3,4-thiadiazol-2-yl)ureido]acetaldehyde
Reaktionsgleichung
[CH:1]1([C:5]2[S:9][C:8]([N:10]=[C:11]=[O:12])=[N:7][N:6]=2)[CH2:4][CH2:3][CH2:2]1.[CH2:13]([NH:16][CH2:17][CH:18]=[O:19])[CH2:14][CH3:15]>C1C=CC=CC=1>[CH2:13]([N:16]([CH2:17][CH:18]=[O:19])[C:11]([NH:10][C:8]1[S:9][C:5]([CH:1]2[CH2:2][CH2:3][CH2:4]2)=[N:6][N:7]=1)=[O:12])[CH2:14][CH3:15]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of 5-cyclobutyl-1,3,4-thiadiazol-2-yl isocyanate dimer (0.05 mole), the dimethyl acetal of 2-propylaminoacetaldehyde (0.1 mole) and benzene (60 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer and reflux condenser. The reaction mixture is heated at reflux for a period of about 15 minutes. After this time the mixture is stripped of benzene under reduced pressure to yield a solid product as the residue. The residue is then recrystallized to yield the desired product the dimethyl acetal of 2-[1-propyl-3-(5cyclobutyl-1,3,4-thiadiazol-2-yl)ureido]acetaldehyde.