Potassium Carbonate → 2-Phenyl-2-(2-cyanomethoxyphenoxy)acetonitrile

HRID 267792

Reaktionsgleichung

Reaktionsgleichung von HRID 267792
[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[O:4][CH2:5][C:6]#[N:7].Cl[CH:13]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:14]#[N:15].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[C:16]1([CH:13]([O:1][C:2]2[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=2[O:4][CH2:5][C:6]#[N:7])[C:14]#[N:15])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Komponenten

5

Edukt 3

HCID 11430Potassium Carbonate2×HCID 123763172-Chloro-2-phenylacetonitrile2×HCID 215539352-(2-Hydroxyphenoxy)acetonitrile

Produkt 1

HCID 215539672-Phenyl-2-(2-cyanomethoxyphenoxy)acetonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A mixture of 2-(2-hydroxyphenoxy)acetonitrile (14.9 g., 0.1 mole), 2-chloro-2-phenylacetonitrile (15.2 g., 0.1 mole), finely powdered potassium carbonate (13.8 g., 0.1 mole) and 80 ml. of acetone is refluxed 3 hours. The mixture is then treated with 2-chloro-2-phenylacetonitrile (7.6 g., 0.05 mole) and potassium carbonate (6.9 g., 0.5 mole) and refluxed six hours. The mixture is filtered, the solids washed with acetone and the combined filtrate evaporated in vacuo to give an oil. Crystallization of the oil affords 2-phenyl-2-(2-cyanomethoxyphenoxy)acetonitrile.

Aufarbeitung

  1. temperaturerefluxed six hours
  2. filtrationThe mixture is filtered
  3. washthe solids washed with acetone
  4. customthe combined filtrate evaporated in vacuo
  5. customto give an oil
  6. customCrystallization of the oil

Quellen und Nachweise

ORD-Eintrag
ord-fb7af966e19f41d4a3a52ead66b7bcdc
Quelldatensatz
uspto-grants-1976_03
Patentnummer
US03944560

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