Aluminum(III) Chloride → 5-Fluoro-2-methylindan-1-one

HRID 267824

Reaktionsgleichung

Reaktionsgleichung von HRID 267824
[Cl-].[Al+3].[Cl-].[Cl-].Br[C:6]([CH3:17])([CH3:16])[C:7]([C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=1)=[O:8]>C(=S)=S>[F:15][C:12]1[CH:11]=[C:10]2[C:9](=[CH:14][CH:13]=1)[C:7](=[O:8])[CH:6]([CH3:17])[CH2:16]2

Komponenten

4

Edukt 2

HCID 6451240Aluminum(III) ChlorideHCID 131131752-Bromo-1-(4-fluorophenyl)-2-methylpropan-1-one

Produkt 1

HCID 30162575-Fluoro-2-methylindan-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6348Carbon DisulfideLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

To a slurry of 120.2 g. (0.90 mole) of anhydrous aluminum chloride in 54 ml. of carbon disulfide is added 122.6 g. (0.50 mole) of 2-bromo-4'-fluoro-2-methylpropiophenone at 15°-20°C over one hour. The mixture is warmed to 50°C over one hour, stirred at 50°C for three hours and quenched in ice. The product is extracted into toluene. The toluene layer is washed with aqueous sodium hydroxide and water and concentrated in vacuo to give 5-fluoro-2-methyl-1-indanone.

Aufarbeitung

  1. customquenched in ice
  2. extractionThe product is extracted into toluene
  3. washThe toluene layer is washed with aqueous sodium hydroxide and water
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1be104609f2e4b2e8727f3bf567c65de
Quelldatensatz
uspto-grants-1976_03
Patentnummer
US03944600

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