Aluminum(III) Chloride → 5-Fluoro-2-methylindan-1-one

HRID 267825

Reaktionsgleichung

Reaktionsgleichung von HRID 267825
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:12])[C:9]([CH3:11])=[CH2:10])=[CH:4][CH:3]=1.[Cl-].[Al+3].[Cl-].[Cl-]>C(=S)=S>[F:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][CH:7]=1)[C:8](=[O:12])[CH:9]([CH3:11])[CH2:10]2

Komponenten

4

Edukt 2

HCID 6451240Aluminum(III) ChlorideHCID 132782011-(4-Fluorophenyl)-2-methylprop-2-en-1-one

Produkt 1

HCID 30162575-Fluoro-2-methylindan-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6348Carbon DisulfideLösungsmittel

Reaktionsbedingungen

Temperatur
45 °C

Versuchsvorschrift

Fifty grams (0.30 moles) of 4'-fluoro-2-methylacrylophenone is added to a slurry of 60.1 g. (0.45 moles) of anhydrous aluminum chloride in 27 ml. of carbon disulfide at 20°-25°C over one hour. The mixture is heated to 45°C over one hour and stirred at 45°C for one hour. The reaction is quenched in ice. The oily aqueous layer is extracted with toluene. The toluene layer is washed with aqueous sodium hydroxide and water and concentrated in vacuo to give 5-fluoro-2-methyl-1-indanone.

Aufarbeitung

  1. customThe reaction is quenched in ice
  2. extractionThe oily aqueous layer is extracted with toluene
  3. washThe toluene layer is washed with aqueous sodium hydroxide and water
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1ff83bf6febf4d849c5a367efe41df33
Quelldatensatz
uspto-grants-1976_03
Patentnummer
US03944600

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