Fluorobenzene → 3-Chloro-1-(4-fluorophenyl)-2-methylpropan-1-one

HRID 267826Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 267826
[Cl-].[Al+3].[Cl-].[Cl-].[F:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[Cl:12][CH2:13][CH:14]([CH3:18])[C:15](Cl)=[O:16]>>[Cl:12][CH2:13][CH:14]([CH3:18])[C:15]([C:9]1[CH:10]=[CH:11][C:6]([F:5])=[CH:7][CH:8]=1)=[O:16]

Komponenten

4

Edukt 3

HCID 10008FluorobenzeneHCID 6451240Aluminum(III) ChlorideHCID 124174873-Chloro-2-methylpropanoyl chloride

Produkt 1

HCID 215218903-Chloro-1-(4-fluorophenyl)-2-methylpropan-1-one

Versuchsvorschrift

To a slurry of 22.7 g. (0.17 mole) of anhydrous aluminum chloride and 9.6 g. (0.10 mole) of fluorobenzene is added 14.1 g. (0.10 mole) of β-chloroisobutyrylchloride over 30 minutes at 20°-25°C. The mixture is aged for 30 minutes at 20°-25°C and then quenched in ice. The product is extracted into hexane. The hexane layer is dried over anhydrous sodium sulfate and concentrated in vacuo to give 3-chloro-4'-fluoro-2-methylpropiophenone.

Aufarbeitung

  1. customquenched in ice
  2. extractionThe product is extracted into hexane
  3. dry with materialThe hexane layer is dried over anhydrous sodium sulfate
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-96591d63f2354f86a084234362a7de28
Quelldatensatz
uspto-grants-1976_03
Patentnummer
US03944600

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