Phenolate Sodium → 2-Amino-3-morpholino-5-phenoxypyrazine

HRID 267956

Reaktionsgleichung

Reaktionsgleichung von HRID 267956
[O-:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Na+].[NH2:9][C:10]1[C:15]([N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)=[N:14][C:13](Br)=[CH:12][N:11]=1>>[NH2:9][C:10]1[C:15]([N:16]2[CH2:17][CH2:18][O:19][CH2:20][CH2:21]2)=[N:14][C:13]([O:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:12][N:11]=1

Komponenten

3

Edukt 2

HCID 4445035Phenolate SodiumHCID 167404415-Bromo-3-morpholinopyrazin-2-amine

Produkt 1

HCID 205289482-Amino-3-morpholino-5-phenoxypyrazine

Versuchsvorschrift

A suspension of 0.1 mole of sodium phenoxide and 0.1 mole of 2-amino-3-morpholino-5-bromopyrazine is refluxed 10-20 hours. The cooled mixture is extracted with diethyl ether, washed with cold 2N sodium hydroxide solution, dried and evaporated to give 2-amino-3-morpholino-5-phenoxypyrazine.

Aufarbeitung

  1. temperatureis refluxed 10-20 hours
  2. extractionThe cooled mixture is extracted with diethyl ether
  3. washwashed with cold 2N sodium hydroxide solution
  4. customdried
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-9597623976764b0983e3a32c3bd58c56
Quelldatensatz
uspto-grants-1976_03
Patentnummer
US03946009

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