HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Potassium Iodide → 5-[4-(alpha-Hydroxy-alpha-phenylbenzyl)piperidino]valerophenone hydrochloride
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Potassium Iodide | HCID 4875 | — |
| Edukt | Azacyclonol | HCID 15723 | — |
| Edukt | 5-Chloro-1-phenyl-1-pentanone | HCID 70338 | — |
| Edukt | Potassium Bicarbonate | HCID 516893 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Produkt | 5-[4-(alpha-Hydroxy-alpha-phenylbenzyl)piperidino]valerophenone hydrochloride | HCID 21552998 | — |
Reaktionsschritte
A mixture of 27.6 g (0.1 mole) of α,α-diphenyl-4-piperidinemethanol, 21.6 g (0.11 mole) of 5-chlorovalerophenone, 20 g of potassium bicarbonate, and 0.1 g of potassium iodide in 300 ml of toluene and 25 ml of water is stirred and refluxed for 136 hours then worked up by the procedure described in Examples 2 and 3 to give 5-[4-(α-hydroxy-α-phenylbenzyl)piperidino]valerophenone hydrochloride, M.P. 162°-164°C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US03946022 |
| Quelldatensatz | uspto-grants-1976_03 |
| ORD ID | ord-ecdb1a75e63c4c2685b929b1aa626727 |
| Quellennotiz | uspto-grants-1976_03 |