Potassium Iodide → Ethyl 2-(p-chlorobenzylthio)-propionate

HRID 26803

Reaktionsgleichung

Reaktionsgleichung von HRID 26803
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][SH:7])=[CH:4][CH:3]=1.Br[CH:11]([CH3:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CC(C)=O>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][S:7][CH:11]([CH3:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:4][CH:3]=1

Komponenten

6

Edukt 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 79040Ethyl 2-bromopropionateHCID 804094-Chlorobenzyl mercaptan

Produkt 1

HCID 20542836Ethyl 2-(p-chlorobenzylthio)-propionate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A mixture of 19.5 ml (0.15 mol) of 4-chlorobenzylmercaptan, 27.1 g (0.15 mol) of ethyl α-bromopropionate, 21 g of potassium carbonate and 0.1 g of potassium iodide in 100 ml of anhydrous acetone is kept under reflux for 6 hrs. It is filtered, the precipitate is washed with acetone and the filtrate is evaporated in vacuo. 200 ml of ether are added to the residue and the mixture is washed with dilute NaOH, dilute HCl and water, dried and evaporated in vacuo.

Aufarbeitung

  1. temperatureunder reflux for 6 hrs
  2. filtrationIt is filtered
  3. washthe precipitate is washed with acetone
  4. customthe filtrate is evaporated in vacuo
  5. addition200 ml of ether are added to the residue
  6. washthe mixture is washed with dilute NaOH, dilute HCl and water
  7. customdried
  8. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6b43ab3bf0e845f9a5b625b6edc154b7
Quelldatensatz
uspto-grants-1979_04
Patentnummer
US04151300

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