Ethanol → 4-Mercapto-phenyl-acetic acid ethyl ester

HRID 268033

Reaktionsgleichung

Reaktionsgleichung von HRID 268033
[SH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.[CH2:12](O)[CH3:13]>Cl>[CH2:12]([O:10][C:9](=[O:11])[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([SH:1])=[CH:7][CH:6]=1)[CH3:13]

Komponenten

4

Edukt 2

HCID 702EthanolHCID 33905114-Mercaptophenylacetic acid

Produkt 1

HCID 123300434-Mercapto-phenyl-acetic acid ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

70 g G 4-mercapto-phenyl-acetic acid are heated at reflux for 30 minutes in 500 cc of 4 N hydrochloric acid in ethanol. The reaction mixture is then completely concentrated at reduced pressure. The oily residue is divided between ether and water, the ether phase is subsequently washed with a 10% sodium bicarbonate solution and water, is dried over sodium sulphate, and the solvent is removed by distillation. The crude 4-mercapto-phenyl-acetic acid ethyl ester, obtained as oily residue, may be purified by distillation; B.P. 103° at 0.4 mm of Hg.

Aufarbeitung

  1. concentrationThe reaction mixture is then completely concentrated at reduced pressure
  2. washthe ether phase is subsequently washed with a 10% sodium bicarbonate solution and water
  3. dry with materialis dried over sodium sulphate
  4. customthe solvent is removed by distillation

Quellen und Nachweise

ORD-Eintrag
ord-d67efbc8ce4a471da27977fd8f368300
Quelldatensatz
uspto-grants-1976_03
Patentnummer
US03946036

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