3-(2'-Methyl-2'-nitrobutyl)-indole → 3-(2'-Amino-2'-methylbutyl)-indole

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

Reduction: A mixture of 90.0 g (388 mM) of the nitro intermediate and 9.0 g of palladium catalyst (5% on carbon) and 1000 ml of absolute ethanol was covered with hydrogen at a pressure of 25 atmospheres gauge in the autoclave whereupon it was heated to 70°C. and agitation was continued at this temperature for 7 hours. Filtration, evaporation in vacuo, recrystallisation from xylene and processing of the mother liquor yielded 74.7 g of 3-(2'-amino-2'-methylbutyl)-indole. (Yield: 95% of the theoretical).

Herkunft & Nachweise