Hydrochloric Acid → 5,7-Dimethylindole

HRID 268676Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 268676
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([CH3:11])[CH:10]=1)[NH:7][C:6](=O)[C:5]2=O.Cl.C(=O)(O)[O-].[Na+]>O1CCCC1>[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([CH3:11])[CH:10]=1)[NH:7][CH:6]=[CH:5]2

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 382965,7-dimethyl-2,3-dihydro-1H-indole-2,3-dioneHCID 516892Sodium Bicarbonate

Produkt 1

HCID 5893955,7-Dimethylindole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

To solution of 5,7-dimethyl-1H-indole-2,3-dione in tetrahydrofuran at 0° C. was added 1.0 M solution of borane-tetrahydrofuran complex in tetrahydrofuran (40 mL). After stirred at room temperature overnight, a 5% HCl solution was added to the mixture and it was stirred 20 minutes. It was neutralized with saturated sodium bicarbonate solution and extracted with ethyl acetate. Extracts were dried over magnesium sulfate and evaporated to dryness to afford the title compound as oil.

Aufarbeitung

  1. stirringwas stirred 20 minutes
  2. extractionextracted with ethyl acetate
  3. dry with materialExtracts were dried over magnesium sulfate
  4. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-df40a1c683f744a0950f484c0ecc2580
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07446122B2

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