HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Trifluoroacetic acid → Trifluoroacetic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Trifluoroacetic acid | HCID 6422 | — |
| Edukt | tert-Butyl 4-(4-cyanophenoxy)piperidine-1-carboxylate | HCID 23019443 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | Trifluoroacetic acid | HCID 6422 | — |
| Produkt | 4-(4-Piperidinyloxy)benzonitrile trifluoroacetate | HCID 17986319 | — |
Reaktionsschritte
4-[(1-tert-Butoxycarbonyl-4-piperidinyl)oxy]benzonitrile (D21) (6.83 g) was dissolved in DCM (30 ml) and TFA (30 ml) was added. The reaction was stirred at rt for 1 h and then evaporated to give the title compound (D22) as a yellow oil (7.15 g—TFA salt plus 1.3 equivalents of TFA).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07446103B2 |
| Quelldatensatz | uspto-grants-2008_11 |
| ORD ID | ord-3fd73069052141f396a29673fdef961f |
| Quellennotiz | uspto-grants-2008_11 |