Hydrochloric Acid → 2-Chloro-4-(piperidin-4-yloxy)-benzonitrile hydrochloride

HRID 268724Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 268724
[Cl:1][C:2]1[CH:9]=[C:8]([O:10][CH:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].Cl>CO.O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:9]=[C:8]([O:10][CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 17986305HCID 17986305, Verbindung

Produkt 1

HCID 179862902-Chloro-4-(piperidin-4-yloxy)-benzonitrile hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

2-Chloro-4-[(1-tert-butoxycarbonyl-4-piperidinyl)oxy]benzonitrile (D29) (5.0 g) was dissolved in methanol (150 ml) and 4N HCl in dioxane (100 ml) was added. The reaction stirred at rt overnight. The reaction mixture was then evaporated to give the title compound (D30) as a white solid (4.0 g).

Aufarbeitung

  1. customThe reaction mixture was then evaporated

Quellen und Nachweise

ORD-Eintrag
ord-5f60f505214a4d989575c79bb5cceb03
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07446103B2

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