Ethylenediamine → N-Methyl-N'-[2-(2-thiazolylmethylamino)ethyl]urea

Reaktionsgleichung

[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH2:6][NH:7][CH2:8][CH2:9][NH2:10].C(N)CN.ClCC1SC=CN=1.[CH3:22][N:23]=[C:24]=[O:25]>>[CH3:22][NH:23][C:24]([NH:10][CH2:9][CH2:8][NH:7][CH2:6][C:2]1[S:1][CH:5]=[CH:4][N:3]=1)=[O:25]

Komponenten

Edukt 4

HCID 3301Ethylenediamine

HCID 12228Methyl Isocyanate

HCID 140908642-(Chloromethyl)-1,3-thiazole

HCID 17944882N-(2-thiazolylmethyl)ethylenediamine

Produkt 1

HCID 20557949N-Methyl-N'-[2-(2-thiazolylmethylamino)ethyl]urea

Versuchsvorschrift

N-(2-Thiazolylmethyl)ethylenediamine, prepared by reacting ethylenediamine with 2-chloromethylthiazole by the procedure of Example 40, is reacted with methyl isocyanate by the procedure of Example 24 to give, after concentrating and separating by column chromatography, the title compound.

Aufarbeitung

customto give
concentrationafter concentrating
customseparating by column chromatography

Quellen und Nachweise

ORD-Eintrag: ord-b7dab71b839d4a05b74897068e5ade89
Quelldatensatz: uspto-grants-1979_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04151288

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