Ethylenediamine → N-Methyl-N'-[2-(3-isothiazolylmethylamino)ethyl]urea

Reaktionsgleichung

[S:1]1[CH:5]=[CH:4][C:3]([CH2:6][NH:7][CH2:8][CH2:9][NH2:10])=[N:2]1.C(N)CN.BrCC1C=CSN=1.[CH3:22][N:23]=[C:24]=[O:25]>>[CH3:22][NH:23][C:24]([NH:10][CH2:9][CH2:8][NH:7][CH2:6][C:3]1[CH:4]=[CH:5][S:1][N:2]=1)=[O:25]

Komponenten

Edukt 4

HCID 3301Ethylenediamine

HCID 12228Methyl Isocyanate

HCID 130375983-(bromomethyl)Isothiazole

HCID 20557777N-(3-isothiazolylmethyl)ethylenediamine

Produkt 1

HCID 20557581N-Methyl-N'-[2-(3-isothiazolylmethylamino)ethyl]urea

Versuchsvorschrift

N-(3-Isothiazolylmethyl)ethylenediamine, prepared by reacting ethylenediamine with 3-bromomethylisothiazole by the procedure of Example 40(a), is reacted with methyl isocyanate by the procedure of Example 24 to give, after concentrating and separating by column chromatography, the title compound.

Aufarbeitung

customto give
concentrationafter concentrating
customseparating by column chromatography

Quellen und Nachweise

ORD-Eintrag: ord-fe698912d47b499d8d612bdfb135dcf8
Quelldatensatz: uspto-grants-1979_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04151288

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