3-Ethynylpyridine → 3-Pyridin-3-ylethynyl-8-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridine
Reaktionsgleichung
I[C:2]1[N:6]2[CH:7]=[C:8]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=3)[CH:9]=[C:10]([C:11]([F:14])([F:13])[F:12])[C:5]2=[N:4][CH:3]=1.[C:25]([C:27]1[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=1)#[CH:26]>>[N:29]1[CH:30]=[CH:31][CH:32]=[C:27]([C:25]#[C:26][C:2]2[N:6]3[CH:7]=[C:8]([C:15]4[CH:16]=[CH:17][C:18]([C:21]([F:23])([F:22])[F:24])=[CH:19][CH:20]=4)[CH:9]=[C:10]([C:11]([F:14])([F:13])[F:12])[C:5]3=[N:4][CH:3]=2)[CH:28]=1Komponenten
3
Versuchsvorschrift
The title compound was prepared from 3-iodo-8-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridine (example C.18 step 6) (460 mg, 1 mmol) and commercially available 3-ethynylpyridine (105 mg, 1 mmol) according to general procedure II. Obtained as a white solid (330 mg, 75%). MS (ISP) 432.1 [(M+H)+]; mp 169-170° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-5ff6c1509974494e922b1a1020bdf88c