5-Bromopyridine-2-carboxamide → 5-[7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-pyridine-2-carboxylic acid amide

HRID 269267

Reaktionsgleichung

Reaktionsgleichung von HRID 269267
[C:1]([C:3]1[CH:4]=[N:5][N:6]2[C:11]([CH:12]([F:14])[F:13])=[CH:10][C:9]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=3)=[N:8][C:7]=12)#[CH:2].Br[C:26]1[CH:27]=[CH:28][C:29]([C:32]([NH2:34])=[O:33])=[N:30][CH:31]=1>>[F:13][CH:12]([F:14])[C:11]1[N:6]2[N:5]=[CH:4][C:3]([C:1]#[C:2][C:26]3[CH:27]=[CH:28][C:29]([C:32]([NH2:34])=[O:33])=[N:30][CH:31]=3)=[C:7]2[N:8]=[C:9]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:23])([F:24])[F:22])=[CH:17][CH:16]=2)[CH:10]=1

Komponenten

3

Edukt 2

HCID 7351515-Bromopyridine-2-carboxamideHCID 866080343-Ethynyl-7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine

Produkt 1

HCID 670009965-[7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-pyridine-2-carboxylic acid amide

Versuchsvorschrift

The title compound was prepared from 3-ethynyl-7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (example C.2) (340 g, 1.0 mmol) and 5-bromo-pyridine-2-carboxylic acid amide (example B.47) (181 mg, 0.9 mmol) according to general procedure II. Obtained as a yellow solid (300 mg, 65%). MS (ISP) 458.1 [(M+H)+]; mp 276-277° C.

Quellen und Nachweise

ORD-Eintrag
ord-16a0f403e1ac49d290d0aefeaf48aa4c
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07446113B2

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