Ethanol → 2-Bromo-5-chlorobenzoic acid ethyl ester

HRID 269554

Reaktionsgleichung

Reaktionsgleichung von HRID 269554
[Br:1][C:2]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH2:12](O)[CH3:13]>S(=O)(=O)(O)O>[Br:1][C:2]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:3]=1[C:4]([O:6][CH2:12][CH3:13])=[O:5]

Komponenten

4

Edukt 2

HCID 702EthanolHCID 890272-Bromo-5-chlorobenzoic acid

Produkt 1

HCID 693095662-Bromo-5-chlorobenzoic acid ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel

Versuchsvorschrift

A solution of 2-bromo-5-chlorobenzoic acid in ethanol (10 ml) and sulphuric acid (0.5 ml) was refluxed for 20 hours then cooled and evaporated. The residue was dissolved in diethyl ether/water and the organic layer dried (magnesium sulphate) and evaporated to give 516 mg of light brown oil.

Aufarbeitung

  1. temperaturethen cooled
  2. customevaporated
  3. dissolutionThe residue was dissolved in diethyl ether/water
  4. dry with materialthe organic layer dried (magnesium sulphate)
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-53864e97ac024a7b8db7f1a8a5c79c24
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07446222B2

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