Hydrochloric Acid → HCID 178479349, Verbindung

HRID 269629Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 269629
[CH2:1]([O:8][C:9](=[O:42])[NH:10][CH2:11][CH2:12][NH:13][C:14](=[O:41])[C@H:15]([CH2:24][CH2:25][CH2:26][NH:27][C:28]([NH:30][C:31]([O:33]CC1C=CC=CC=1)=[O:32])=[NH:29])[NH:16]C(OC(C)(C)C)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:43]>O1CCOCC1>[ClH:43].[CH2:1]([N:30]([C:28](=[NH:29])[NH:27][CH2:26][CH2:25][CH2:24][C@H:15]([NH2:16])[C:14](=[O:41])[NH:13][CH2:12][CH2:11][NH:10][C:9](=[O:42])[O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:31](=[O:32])[OH:33])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 178454188HCID 178454188, Verbindung

Produkt 1

HCID 178479349HCID 178479349, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A mixture of 334 mg (0.417 mmol) of benzyl (2-{[N5-[{[(benzyloxy)carbonyl]amino}(imino)methyl]-N2-(tert-butoxycarbonyl)-L-ornithyl]amino}ethyl)carbamate (Example 102A) and 17 ml of a 4M solution of hydrogen chloride in dioxane is stirred at RT for 4 h. The reaction solution is concentrated, coevaporated with dichloromethane several times, and dried under high vacuum. The crude product is reacted without further purification.

Aufarbeitung

  1. concentrationThe reaction solution is concentrated
  2. customdried under high vacuum
  3. customThe crude product is reacted without further purification

Quellen und Nachweise

ORD-Eintrag
ord-3ff67b89f62c45d486058ea0410e3575
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07446102B2

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