Hydrochloric Acid → benzyl((1S)-4-amino-1-{2-[(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-oxoethyl}butyl)carbamate hydrochloride

HRID 269631Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 269631
[ClH:1].[CH2:2]([O:9][C:10](=[O:41])[NH:11][CH2:12][CH2:13][NH:14][C:15](=[O:40])[CH2:16][C@@H:17]([NH:29][C:30]([O:32]CC1C=CC=CC=1)=[O:31])[CH2:18][CH2:19][CH2:20][NH:21]C(OC(C)(C)C)=O)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>O1CCOCC1>[ClH:1].[CH2:2]([N:29]([C@H:17]([CH2:16][C:15]([NH:14][CH2:13][CH2:12][NH:11][C:10]([O:9][CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1)=[O:41])=[O:40])[CH2:18][CH2:19][CH2:20][NH2:21])[C:30](=[O:31])[OH:32])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 86624500HCID 86624500, Verbindung

Produkt 1

HCID 69216382benzyl((1S)-4-amino-1-{2-[(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-oxoethyl}butyl)carbamate hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

8 ml of a 4M solution of hydrogen chloride in dioxane are added to a solution of 320 mg (0.287 mmol) of benzyl[2-({(3S)-3-{[(benzyloxy)carbonyl]amino}-6-[(tert-butoxycarbonyl)amino]hexanoyl}amino)ethyl]carbamate (Example 104A) in 2 ml of dioxane at 0° C. After 1 h at RT, the reaction solution is concentrated in vacuo, coevaporated with dichloromethane several times and dried under high vacuum. The crude product is reacted without further purification.

Aufarbeitung

  1. concentrationthe reaction solution is concentrated in vacuo
  2. customdried under high vacuum
  3. customThe crude product is reacted without further purification

Quellen und Nachweise

ORD-Eintrag
ord-16282749c19d4fb582becedfe43dd038
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07446102B2

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