HCID 70806691, Verbindung → HCID 50940432, Verbindung

Reaktionsgleichung

C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][C@@H:11]1[NH:29][C:28](=[O:30])[C@@H:27]([NH:31]C(OC(C)(C)C)=O)[CH2:26][C:25]2[CH:39]=[C:21]([CH:22]=[CH:23][C:24]=2[OH:40])[C:20]2=[CH:41][C:16](=[C:17]([OH:42])[CH:18]=[CH:19]2)[CH2:15][C@@H:14]([C:43]([NH:45][CH2:46][CH2:47][CH2:48][C@H:49]([NH2:57])[CH2:50][C:51]([NH:53][CH2:54][CH2:55][NH2:56])=[O:52])=[O:44])[NH:13][C:12]1=[O:58])(C)(C)C.[H][H].[Cl-:62].O1CCOCC1>>[ClH:62].[ClH:62].[ClH:62].[ClH:62].[NH2:31][C@H:27]1[CH2:26][C:25]2[CH:39]=[C:21]([CH:22]=[CH:23][C:24]=2[OH:40])[C:20]2=[CH:41][C:16](=[C:17]([OH:42])[CH:18]=[CH:19]2)[CH2:15][C@@H:14]([C:43]([NH:45][CH2:46][CH2:47][CH2:48][C@H:49]([NH2:57])[CH2:50][C:51]([NH:53][CH2:54][CH2:55][NH2:56])=[O:52])=[O:44])[NH:13][C:12](=[O:58])[C@H:11]([CH2:10][CH2:9][CH2:8][NH2:7])[NH:29][C:28]1=[O:30]

Komponenten

Edukt 3

HCID 70806691HCID 70806691, Verbindung

HCID 86639075HCID 86639075, Verbindung

HCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 50940432HCID 50940432, Verbindung

Versuchsvorschrift

8 mg (0.010 mmol) of tert-butyl{3-[(8S,11S,14S)-8-[({(4S)-4-amino-6-[(2-aminoethyl)amino]-6-oxohexyl}amino)carbonyl]-14-[(tert-butoxycarbonyl)amino]-5,17-dihydroxy-10,13-dioxo-9,12-diazatricyclo[14.3.1.12,6]henicosa-1(20),2(21),3,5,16,18-hexaen-11-yl]propyl}carbamate bis(hydroacetate) (Example 206A) are added into 0.4 ml of a 4N solution of hydrogen in dioxane chloride and stirred at RT for 30 min. The reaction solution is concentrated, coevaporated with dichloromethane several times and dried under high vacuum.