Piperidine → HCID 69181070, Verbindung

HRID 269793Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 269793
[N+:1]([N:4]1[C:9](=[O:10])[CH:8]=[CH:7][NH:6][C:5]1=[O:11])([O-:3])=[O:2].N1CCC[CH2:14][CH2:13]1>C(O)C>[CH:13]([C:8]1[C:9](=[O:10])[N:4]([N+:1]([O-:3])=[O:2])[C:5](=[O:11])[NH:6][CH:7]=1)=[CH2:14]

Komponenten

4

Edukt 2

HCID 8082PiperidineHCID 1513582,4(1H,3H)-Pyrimidinedione, nitro-

Produkt 1

HCID 69181070HCID 69181070, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

As shown in Scheme 1, a suitable nitro-uracil precursor, (1), is mixed with an appropriate aldehyde, (2), and piperidine, in a suitable solvent such as ethanol. The solution is heated to reflux for approximately 10-20 hours. After reflux, the mixture is concentrated and purified using conventional methods, such as thin layer chromatography, to produce the vinyl-nitro-uracil (3).

Aufarbeitung

  1. temperatureThe solution is heated
  2. temperatureto reflux for approximately 10-20 hours
  3. temperatureAfter reflux
  4. concentrationthe mixture is concentrated
  5. custompurified

Quellen und Nachweise

ORD-Eintrag
ord-8c6aeed16de9417a8f4b15f68c80124a
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07449473B2

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