1-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine → 2-Fluoro-4-[4-(3-phenylpropyl)piperazin-1-yl]phenol

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	1-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine	HCID 23111408	—
Edukt	1-(4-Benzyloxy-3-fluorophenyl)-4-(3-phenylpropyl)-piperazine	HCID 23111437	—
Produkt	2-Fluoro-4-[4-(3-phenylpropyl)piperazin-1-yl]phenol	HCID 23111406	73,1%

Reaktionsschritte

Production Example 30 was repeated except that 1-(4-benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine was replaced with 1-(4-benzyloxy-3-fluorophenyl)-4-(3-phenylpropyl)-piperazine (394 mg). The resulting crude product was purified on TLC (developer, chloroform: methanol=10:1) to provide 2-fluoro-4-[4-(3-phenylpropyl)piperazin-1-yl]phenol (224 mg).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07449466B2
Quelldatensatz	uspto-grants-2008_11
ORD ID	ord-afb87b17d5614531bf0bf79ebf153926
Quellennotiz	uspto-grants-2008_11