HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-Phenethylpiperazine → 4-(3-Cyclohexylpropyl)-1-(2,5-difluoro-4-methoxyphenyl)piperidine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-Phenethylpiperazine | HCID 79214 | — |
| Edukt | 4-Bromo-1-methoxy-2-methylbenzene | HCID 608315 | — |
| Edukt | 4-Bromo-2,5-difluoroanisole | HCID 2724983 | — |
| Edukt | 4-(3-Cyclohexylpropyl)-piperidine | HCID 23111496 | — |
| Produkt | 4-(3-Cyclohexylpropyl)-1-(2,5-difluoro-4-methoxyphenyl)piperidine | HCID 23111463 | 98,2% |
Reaktionsschritte
Production Example 9 was repeated except that 5-bromo-2-methoxytoluene and 1-phenethylpiperazine were replaced with 4-bromo-2,5-difluoroanisole (338 mg) and 4-(3-cyclohexylpropyl)-piperidine (953 mg), respectively. The resulting crude product was purified on silica gel column chromatography (eluent, hexane: ethyl acetate=3:1) to provide 4-(3-cyclohexylpropyl)-1-(2,5-difluoro-4-methoxyphenyl)piperidine (523 mg).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07449466B2 |
| Quelldatensatz | uspto-grants-2008_11 |
| ORD ID | ord-5b3ee35c5f6748ad81787f6e55408130 |
| Quellennotiz | uspto-grants-2008_11 |