HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-Bromooctane → 1-(3-Cyclohexylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-Bromooctane | HCID 8140 | — |
| Edukt | 3-Cyclohexylpropyl methanesulfonate | HCID 23111443 | — |
| Edukt | 1-(4-Benzyloxy-3-fluorophenyl)piperazine | HCID 23111483 | — |
| Edukt | 1-(2,5-Difluoro-4-methoxyphenyl)piperazine | HCID 23111492 | — |
| Produkt | 1-(3-Cyclohexylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine | HCID 23111426 | 97,6% |
Reaktionsschritte
Production Example 38 was repeated except that 1-(4-benzyloxy-3-fluorophenyl)piperazine and n-octyl bromide were replaced with 1-(2,5-difluoro-4-methoxyphenyl)piperazine (5.72 g) and 3-cyclohexylpropyl methanesulfonate (5.52 g), to provide crude 1-(3-cyclohexylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine (8.618 g).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07449466B2 |
| Quelldatensatz | uspto-grants-2008_11 |
| ORD ID | ord-1b0415f35aed4884926bf0f098b46b1e |
| Quellennotiz | uspto-grants-2008_11 |