C(OC(=O)N)(C)(C)C.[NH2:9][CH2:10][CH2:11][NH:12][S:13]([C:16]1[C:17]2[CH:18]=[CH:19][N:20]=[CH:21][C:22]=2[CH:23]=[C:24]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:25]=1)(=[O:15])=[O:14].C(Cl)[Cl:33].Cl>CO>[ClH:33].[NH2:9][CH2:10][CH2:11][NH:12][S:13]([C:16]1[C:17]2[CH:18]=[CH:19][N:20]=[CH:21][C:22]=2[CH:23]=[C:24]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:25]=1)(=[O:15])=[O:14]7-Phenyl-isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide carbamic acid t-butyl ester (1.44 g, 3.37 mmol) is dissolved in CH3OH (20 mL) and CH2Cl2 (20 mL) and HCl (37%, 5.0 mL) is added. After the mixture is stirred overnight, the mixture is concentrated and dried under high vacuum to give 1.34 g (100% yield) 7-phenyl-isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide hydrochloride. Load the product onto ion exchange resin and elute with 1N NH3 in methanol and concentrate to dryness to give the free base.
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