Trifluoroacetic acid → 4-Acetamido-3-hydroxyphenyl acetate

HRID 270087Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 270087
[C:1]([O:4][C:5]1[CH:14]=[CH:13][C:8]2[N:9]=[C:10]([CH3:12])[O:11][C:7]=2[CH:6]=1)(=[O:3])[CH3:2].FC(F)(F)C(O)=[O:18].C(=O)([O-])O.[Na+]>O1CCCC1>[C:1]([O:4][C:5]1[CH:14]=[CH:13][C:8]([NH:9][C:10](=[O:18])[CH3:12])=[C:7]([OH:11])[CH:6]=1)(=[O:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 6422Trifluoroacetic acidHCID 516892Sodium BicarbonateHCID 156622632-Methylbenzo[d]oxazol-6-yl acetate

Produkt 1

HCID 688181524-Acetamido-3-hydroxyphenyl acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

2-methyl-1,3-benzoxazol-6-yl acetate (8.1 g, 42.3 mmol) was dissolved in tetrahydrofuran (60 mL), and trifluoroacetic acid (4 mL, 53.2 mmol) was added. The light brown solution was stirred over night at room temperature. Sodium hydrogen carbonate (aq, sat) was added, and the solution was extracted twice with ethyl acetate. The combined organic layers were concentrated to the titled compound (8.0 g, 91%) as a beige solid.

Aufarbeitung

  1. extractionthe solution was extracted twice with ethyl acetate
  2. concentrationThe combined organic layers were concentrated to the titled compound (8.0 g, 91%) as a beige solid

Quellen und Nachweise

ORD-Eintrag
ord-d8dbe9912e804bef8afffdec1554dd7c
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07449475B2

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