Dimethylcarbamoyl Chloride → 1-(N,N-Dimethylcarbamoyl)-4,5-dicyanoimidazole

HRID 27032

Reaktionsgleichung

Reaktionsgleichung von HRID 27032
O1CCOCC1.[C:7]([C:9]1[N:10]=[CH:11][NH:12][C:13]=1[C:14]#[N:15])#[N:8].C(N(CC)CC)C.[CH3:23][N:24]([CH3:28])[C:25](Cl)=[O:26]>>[CH3:23][N:24]([CH3:28])[C:25]([N:10]1[C:9]([C:7]#[N:8])=[C:13]([C:14]#[N:15])[N:12]=[CH:11]1)=[O:26]

Komponenten

5

Edukt 4

HCID 6598Dimethylcarbamoyl ChlorideHCID 8471TriethylamineHCID 312751,4-DioxaneHCID 707294,5-Dicyanoimidazole

Produkt 1

HCID 233434181-(N,N-Dimethylcarbamoyl)-4,5-dicyanoimidazole

Versuchsvorschrift

To 50 ml of dry 1,4-dioxane 6.0 g (0.05 mole) of 4,5-dicyanoimidazole, 5.0 g (0.05 mole) of triethylamine and 6.0 g (0.055 mole) of dimethylcarbamoyl chloride are added in succession at room temperature. This mixture is stirred and refluxed for 3 days, cooled to room temperature and evaporated to dryness. The residue is stirred in 50 ml of ethyl acetate and 50 ml water. The organic layer is separated, washed, dried and evaporated to give 8 g. (85%) of white product.

Aufarbeitung

  1. temperaturerefluxed for 3 days
  2. customevaporated to dryness
  3. stirringThe residue is stirred in 50 ml of ethyl acetate
  4. customThe organic layer is separated
  5. washwashed
  6. customdried
  7. customevaporated
  8. customto give 8 g

Quellen und Nachweise

ORD-Eintrag
ord-ccbdcc529e104ca9a8cdaf4b5e1e4621
Quelldatensatz
uspto-grants-1980_09
Patentnummer
US04220466

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