Dimethylformamide → 1-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-(4-iodo-3,5-dimethyl-pyrazol-1-yl)-ethanone

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Dimethylformamide	HCID 6228	—
Edukt	Potassium Carbonate	HCID 11430	—
Edukt	3,5-Dimethyl-4-iodo-1H-pyrazole	HCID 97115	—
Edukt	1-(Chloroacetyl)-4-(4-fluorophenyl)piperazine	HCID 1848511	—
Lösungsmittel	Ethyl acetate hexane	HCID 21226206	—
Produkt	1-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-(4-iodo-3,5-dimethyl-pyrazol-1-yl)-ethanone	HCID 21071008	—

Reaktionsschritte

Protocol T was followed using 4-Iodo-3,5-dimethyl-pyrazole, K2CO3, 2-Chloro-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=1/1) afforded the title compound as a white solid. 1H NMR (400 MHz, CDCl3); 6.95-7.1 (m, 2H), 6.84-6.92 (dd, 2H), 5.00 (s, 2H), 3.62-3.82 (m, 4H), 3.02-3.12 (m, 4H), 2.22-2.32 (d, 6H). 13C NMR (400 MHz, CDCl3): 165, 158.2, 156.2, 150.2, 146.8, 141.8, 118.8, 115.4, 115.2, 52.8, 51.6, 50.2, 45.2, 42, 14.8, 12.6.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07449576B1
Quelldatensatz	uspto-grants-2008_11
ORD ID	ord-0b071b0a9d6a427ebf3d2144538b0d8a
Quellennotiz	uspto-grants-2008_11