Dimethylformamide → 1-[4-(4-Chloro-3-methoxyphenyl)-piperazin-1-yl]-2-(4-chloro-5-phenyl-3-trifluoromethyl-pyrazol-1-yl)-ethanone

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Dimethylformamide	HCID 6228	—
Edukt	Potassium Carbonate	HCID 11430	—
Edukt	2-Chloro-1-(4-(4-chloro-3-methoxyphenyl)piperazin-1-yl)ethanone	HCID 21071126	—
Edukt	HCID 178506302	HCID 178506302	—
Lösungsmittel	Ethyl acetate hexane	HCID 21226206	—
Produkt	1-[4-(4-Chloro-3-methoxyphenyl)-piperazin-1-yl]-2-(4-chloro-5-phenyl-3-trifluoromethyl-pyrazol-1-yl)-ethanone	HCID 21070990	—

Reaktionsschritte

Protocol T was followed using 4-Chloro-5-phenyl-3-trifluoromethyl-1H-pyrazole, K2CO3, 2-Chloro-1-[4-(4-chloro-3-methoxy-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=2/3, Rf=0.92) afforded the title compound as a white solid. 1H NMR (400 MHz, CDCl3): 7.78-7.84 (m, 2H), 7.36-7.52 (m, 4H), 6.38-6.48 (m, 2H), 5.2 (s, 2H), 3.88 (s, 3H), 3.62-3.78 (m, 4H), 3.18-3.26 (s, 4H). 13C NMR (400 MHz, CDCl3) 164.4, 156, 150.4, 130.4, 130, 128.6, 110.2, 102.4, 56.4, 52, 50.4, 44.6, 42.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07449576B1
Quelldatensatz	uspto-grants-2008_11
ORD ID	ord-a9f4d53af1ae4a2ca28fc8426c1b1ca9
Quellennotiz	uspto-grants-2008_11