Nabumetone → Nabumetone 2,3-naphthalenediol

HRID 271035

Reaktionsgleichung

Reaktionsgleichung von HRID 271035
[CH3:1][C:2]([CH2:4][CH2:5][C:6]1[CH:7]=[CH:8][C:9]2[CH:10]=[C:11]([O:16][CH3:17])[CH:12]=[CH:13][C:14]=2[CH:15]=1)=[O:3].[CH:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:21]=[C:20]([OH:28])[C:19]=1[OH:29]>[N+](C)([O-])=O>[CH:21]1[C:22]2[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:18]=[C:19]([OH:29])[C:20]=1[OH:28].[CH3:1][C:2]([CH2:4][CH2:5][C:6]1[CH:7]=[CH:8][C:9]2[CH:10]=[C:11]([O:16][CH3:17])[CH:12]=[CH:13][C:14]=2[CH:15]=1)=[O:3].[CH:13]1[C:14]2[C:9](=[CH:8][CH:7]=[CH:6][CH:15]=2)[CH:10]=[C:11]([OH:16])[C:12]=1[OH:28]

Komponenten

5

Edukt 2

HCID 4409Nabumetone2×HCID 70912,3-Dihydroxynaphthalene

Produkt 2

HCID 70912,3-DihydroxynaphthaleneHCID 67107975Nabumetone 2,3-naphthalenediolAusbeute 68 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6375NitromethaneLösungsmittel

Versuchsvorschrift

As a demonstrative example, a cocrystal comprising a neutral API is described in this example. Cocrystals of nabumetone (a neutral API) and 2,3-naphthalenediol were prepared as follows. A 4.01 g sample of 2,3-naphthalenediol and 5.7 g of nabumetone were dissolved in 50 mL of nitromethane with heating. A solid was formed as the solution cooled and was allowed to stand overnight. The solid was filtered from the remaining solvent and dried in the air to yield 6.61 g (68%) of nabumetone:2,3-naphthalenediol (1:1) cocrystal.

Aufarbeitung

  1. temperaturewith heating
  2. customA solid was formed as the solution
  3. temperaturecooled
  4. filtrationThe solid was filtered from the remaining solvent
  5. customdried in the air

Quellen und Nachweise

ORD-Eintrag
ord-f4aa8ea5a5884b2695c8e9085aab7d64
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07452555B2

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