Ethanol → Ethyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate

HRID 271235Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 271235
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12](=[O:13])[CH2:11][CH:10]([C:14]([OH:16])=[O:15])[CH2:9]2)=[CH:4][CH:3]=1.[CH2:17](O)[CH3:18]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12](=[O:13])[CH2:11][CH:10]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:9]2)=[CH:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 702EthanolHCID 29126521-(4-Fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid

Produkt 1

HCID 21935588Ethyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid (unknown amount) was dissolved in 20 ml ethanol and cooled to 0° C. HCl gas was bubbled into the solution until the solution became red in color. The reaction was allowed to warm to room temperature and stir ovenight. The solvent was removed to yield ethyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate (M+1=251.93).

Aufarbeitung

  1. customHCl gas was bubbled into the solution until the solution
  2. temperatureto warm to room temperature
  3. customThe solvent was removed

Quellen und Nachweise

ORD-Eintrag
ord-3c074810df3c4d3c99c269f3996b7ca9
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07452889B2

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