2-Chloro-6-methylbenzoic acid → (2S)-2-(2-chloro-6-methyl-benzoylamino)-3-[4-(4-methyl-1,3-dioxo-1,3-dihydroisoindole-2-yl)phenyl]propionic acid ethylester

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	2-Chloro-6-methylbenzoic acid	HCID 88870	—
Edukt	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride	HCID 2723939	—
Edukt	1-Hydroxybenzotriazole hydrate	HCID 2796029	—
Edukt	(2S)-2-amino-3-[4-(4-methyl-1,3-dioxo-1,3-dihydroisoindole-2-yl)phenyl]propionic acid ethylester hydrochloride	HCID 66960581	—
Lösungsmittel	Dichloromethane	HCID 6344	—
Lösungsmittel	Triethylamine	HCID 8471	—
Produkt	(2S)-2-(2-chloro-6-methyl-benzoylamino)-3-[4-(4-methyl-1,3-dioxo-1,3-dihydroisoindole-2-yl)phenyl]propionic acid ethylester	HCID 68456847	—

Reaktionsbedingungen

Temperatur	45 °C

Reaktionsschritte

The mixture of 88.2 mg of 2-chloro-6-methyl benzoic acid, 99.1 mg of 1-(3-dimehtylaminopropyl)-3-ethylcarbodiimide hydrochloride, 79.1 mg of 1-hydroxybenzotriazol hydrate, 107 μl of triethylamine, 100 mg of (2S)-2-amino-3-[4-(4-methyl-1,3-dioxo-1,3-dihydroisoindole-2-yl)phenyl] propionic acid ethylester hydrochloride and 1 ml of dichloromethane was stirred at 45° C. overnight. The mixture was purified by silica gel chromatography to obtain the title compound.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07452905B2
Quelldatensatz	uspto-grants-2008_11
ORD ID	ord-ec3a57bbe2fa426fb62dad6b2b7ac4f2
Quellennotiz	uspto-grants-2008_11