Thionyl Chloride → 6-Chloromethyl-2-methylpyridinium chloride

HRID 271504

Reaktionsgleichung

Reaktionsgleichung von HRID 271504
O[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[N:4]=1.S(Cl)([Cl:12])=O>>[ClH:12].[Cl:12][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[N:4]=1

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 707366-Methyl-2-pyridylmethanol

Produkt 1

HCID 765456-Chloromethyl-2-methylpyridinium chloride

Versuchsvorschrift

2-(Hydroxymethyl)-6-methylpyridine (3.7 g, 29.4 mmol) was added portion wise at 0° C. to thionylchloride (35 mL, 477 mmol). The reaction mixture was then stirred at room temperature for 18 h. Excess thionylchloride was removed under vacuum and the crude 2-chloromethyl-6-methyl-pyridine hydrochloride (5.1 g, light brown solid) was used without any further purification.

Aufarbeitung

  1. customExcess thionylchloride was removed under vacuum
  2. customthe crude 2-chloromethyl-6-methyl-pyridine hydrochloride (5.1 g, light brown solid) was used without any further purification

Quellen und Nachweise

ORD-Eintrag
ord-e3da7e44a8a044e1952bd9eaa4e48c54
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07452909B2

Verknüpfte Notizen

Wird geladen…