Trifluoroacetic acid → Trifluoroacetic acid

HRID 271902

Reaktionsgleichung

Reaktionsgleichung von HRID 271902
COC1C=C(OC)C=CC=1C[N:6]1[C:11]2C=CC=N[C:10]=2[CH2:9][N:8](C2CCN(C(OC(C)(C)C)=O)CC2)[C:7]1=[O:29].[F:36][C:37]([F:42])([F:41])[C:38]([OH:40])=[O:39]>>[C:38]([OH:40])([C:37]([F:42])([F:41])[F:36])=[O:39].[NH:8]1[CH:9]=[CH:10][CH:11]=[N:6][C:7]1=[O:29]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 22293253tert-Butyl 4-[1-(2,4-dimethoxybenzyl)-2-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-3(2H)-yl]piperidine-1-carboxylate

Produkt 2

HCID 6422Trifluoroacetic acidHCID 684012(1H)-Pyrimidinone

Versuchsvorschrift

tert-Butyl 4-[1-(2,4-dimethoxybenzyl)-2-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-3(2H)-yl]piperidine-1-carboxylate (0.10 g, 0.21 mmol) was dissolved in trifluoroacetic acid (5 mL) and stirred overnight. The reaction was concentrated to afford the bis-TFA salt of the title compound (0.048 g). MS 233.2 (M+1).

Aufarbeitung

  1. concentrationThe reaction was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-93766037067847f196c43d97405c4735
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07452903B2

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